Scientific report 2022 of the Cellular Therapy and Immunobiology Working Party (CTIWP)
The CTIWP activities are evolving quickly with the new treatments and different scenarios in the HCT, cell and gene therapy fields.
The CTIWP has been working to expand and moderate the CAR T community through partnerships with other organisations such as the GoCART coalition and T2Evolve. The CTIWP has also worked with national registries like OncodePACT to secure funding for connecting these registries to national databases and increase the impact of the EBMT-based CAR T registry. In addition, the CTIWP has collaborated with the regulatory affairs community of EBMT to provide input on European legislation related to stem cell transplantation and cellular therapies, and to facilitate academic development and improve access to approved drugs. The CTIWP has also helped to harmonize the accreditation process for centers that perform CAR T therapies in collaboration with JACIE and GoCART, to avoid duplication of efforts (Reduced CART site qualification workload for JACIE accredited centres | EBMT).
Understanding the biological mechanisms that may influence the HCT outcomes are among the main objectives of the CTIWP. The role of new tools for evaluating the impact of HLA in the setting of allogeneic transplantation in unrelated and also mismatched related donors transplant with the use of PTCY is currently under investigation. Different studies are ongoing exploring the role of HLA evolutionary divergence, and the role of the quantification of HLA-DP mismatch permissiveness. Also focusing on the role of microbiota for GVHD treatment or decontamination in case of multidrug resistant carriages is a topic of interest, such as the management of complications related to the cell therapy treatments
Principal research studies
- 48th Annual Meeting of the EBMT: Cell Therapy Day
- 48th Annual Meeting of the EBMT: CTIWP session
- CTIWP Scientific Business Meeting - June 15, 2022
- CTIWP Scientific Business Meeting - Sep. 30, 2022
- Joint Meeting of the ALWP and CTIWP (Virtual) - Sep. 30 - Oct. 1, 2022