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A comparison between ATG and PT-CY graft-versus-host-disease prophylaxis in patients with lymphoma undergoing reduced intensity conditioning regimen HSCT from 1 antigen MMUD

Study number:
2019-R-05
Diseases:
 
Short title:
ATG vs PT-Cy in 1 MMUD
Study status:
Data collection
Deadline for data collection:
Study design:
Retrospective registry analysis
Primary objective:
To retrospectively analyze outcomes after first allogenic hematopoietic stem cell transplantation (HSCT) from MMUD 9/10 with a reduced intensity conditioning (RIC) regimen comparing outcomes of PT-CY versus ATG as GVHD prophylaxis in patients with lymphoproliferative disorders
Key inclusion criteria:
Inclusion criteria:
-Patients who received a 9/10 HSCT
-First HSCT (previous autologous transplantation accepted)
-High-resolution HLA allele typing at loci A, B, C, DRB1 and DQ available
-Stem Cell source (bone marrow or peripheral blood stem cells)
-Year of HSCT from 2010 to 2018
-All type of B and T cell lymphomas (NHL and HL, aggressive and indolent)
-All disease status at HSCT
-RIC regimen
-In vivo T cell depletion (TCD) with ATG (other in vivo TCD excluded) or PT-CY

Exclusion criteria:
-Cord Blood as stem cell source
-Other type of unrelated HSCT (matched unrelated, more than 1 mismatch)
Country:
 
Principal investigator:
Annalisa Paviglianiti
Principal investigator email:
annalisapaviglianiti@gmail.com
EBMT Study coordinator:
Hervé Finel
Study coordinator email:
herve.finel@upmc.fr