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Chimera

Welcome to Chimera,

The first-ever online and open-access education e-course, brought to you by The EBMT Trainee Committee, designed to cover all aspects surrounding hematopoietic cell transplantation and cellular therapy with a focus on trainee-relevant knowledge and skills.

The e-course is divided into several learning modules, each covering separate topics and learning goals. Within a module, sub-topics are divided into short 10 minutes trainee-focused presentations delivered by an expert in the field. At the end of each module, there will be a short quiz to summarize the learning objectives and enable you to obtain a certificate to keep for your records. The module content can be reviewed as often as you wish, and the quiz can be attempted a number of times so no need to stress.

We are particularly happy that this whole project has come together through an international collaboration of trainees living and working across the globe, clearly highlighting what can be achieved when people share the same common goal of facilitating access to training resources. We may be based across countries and oceans, and have never actually met in person, but all share the same enthusiasm and determination for addressing inequalities in training opportunities. Each module has its own coordinating group who will introduce its goals and structure in short introductory videos.

This is a living learning e-course, so modules will be added over the next weeks and months. If you have any ideas for further refinements, please leave us your feedback and share your critique, feel free to e-mail us directly. We welcome you all to enjoy this project and join us on our exciting journey through the evolving field of BMT and cellular therapy.

For now, just create an account and enjoy this learning experience for free!

Claire Horgan and Nico Gagelmann,

on behalf of the EBMT Trainee Committee

Cells

Start your learning journey

Go to the e-learning platform!

Learning objectives

  • Provide trainees with a basic knowledge and understanding of bone marrow transplant and cellular therapies.
  • Understand the processes involved in stem cell transplant.
  • Familiarize trainees with important clinical aspects of stem cell transplant and cellular therapy, including pharmacology, patient monitoring, and recognition and basic management of complications.

Modules

Pharmacology Part 1: Conditioning

Log in to get a sneak peek of the latest Chimera Module: Pharmacology Part 1.  

Lecture:

  • Introduction to conditioning therapy - Daniele Avenoso

 Stay tuned for the rest of the module, coming soon!
 

VOD

Lectures:
  • VOD – diagnosis, risk factors and red flags, management, prognosis - Mohamad Mohty
Learning objectives:
  1. Acquire tools to identify patients at high risk of developing VOD/SOS and strategies to reduce this risk.
  2. Familiarise with key elements of diagnosis and risk stratification.
  3. Highlight the importance of early identification of VOD/SOS and early treatment initiation.

Finding the donor

Lectures:
  • HLA typing and compatibility - Eric Spierings
  • Donor types (part I) - Adriana Balduzzi
  • Donor types (part II) - Adriana Balduzzi
  • Donor types (part III) - Adriana Balduzzi
  • Donor types (part IV) - Adriana Balduzzi
  • Donor registries - Lydia Foeken
  • Transplant coordination - Christina Holm
Learning objectives:
  1. To understand the main role of the human leukocyte antigen (HLA) system in immune responses and in the context of allogeneic haematopoietic cell transplantation.
  2. To gain insight into which criteria matter – and how – when selecting a donor for allogeneic transplantation.
  3. To understand the role and organisation of haematopoietic cell donor registries.
  4. To learn how an allogeneic transplantation is planned and coordinated.

Cellular therapy at home

Lectures:
  • At-Home Stem Cell Transplantation - Francesc Fernández Avilés
  • Outpatient/at-home management for CAR-T cell patients - Alexandra Martínez Roca
Learning objectives:
  1. Understand the logistic elements necessary to perform an at-home program for autologous and allogenic haematopoietic stem cell transplantation as well as CAR-T cell therapy.
  2. Identify how at-home programs can improve the quality of life of patients and caregivers and reduce medical costs.
  3. Recognise the prophylactic measures for preventing patient readmission.
  4. Assess the requirements to implement and manage at-home programs.
  5. Identify how to manage the adverse events in an outpatient/at-home setting.

Getting the Cells

Lectures:
  • Bone marrow harvesting - Iñigo Romon
  • Peripheral blood stem cell mobilization and apheresis - Daan Dierickx
  • Procurement and management of cord blood - Sergio Querol
  • Graft processing and manipulation - Sergio Querol
Learning objectives:
  1. Understand the procedure of bone marrow harvesting, including practical considerations, target cell yield, and potential risks and complications.
  2. Learn how haematopoietic progenitor cells (HPCs) are mobilised to and collected from peripheral blood, including the mechanism of action of G-CSF and the indications of different mobilisation regimes.
  3. Be able to identify and manage complications and side effects of HPC mobilisation and apheresis, including “poor mobilisers”.
  4. Understand how HPCs can be collected from cord blood and the setup of cord blood banks for this purpose.
  5. Gain knowledge about the main types of graft processing, including cryopreservation, plasma reduction, red blood cell depletion, and cell selection.