Welcome to Chimera,
The first-ever online and open-access education e-course, brought to you by The EBMT Trainee Committee, designed to cover all aspects surrounding hematopoietic cell transplantation and cellular therapy with a focus on trainee-relevant knowledge and skills.
The e-course is divided into several learning modules, each covering separate topics and learning goals. Within a module, sub-topics are divided into short 10 minutes trainee-focused presentations delivered by an expert in the field. At the end of each module, there will be a short quiz to summarize the learning objectives and enable you to obtain a certificate to keep for your records. The module content can be reviewed as often as you wish, and the quiz can be attempted a number of times so no need to stress.
We are particularly happy that this whole project has come together through an international collaboration of trainees living and working across the globe, clearly highlighting what can be achieved when people share the same common goal of facilitating access to training resources. We may be based across countries and oceans, and have never actually met in person, but all share the same enthusiasm and determination for addressing inequalities in training opportunities. Each module has its own coordinating group who will introduce its goals and structure in short introductory videos.
This is a living learning e-course, so modules will be added over the next weeks and months. If you have any ideas for further refinements, please leave us your feedback and share your critique, feel free to e-mail us directly. We welcome you all to enjoy this project and join us on our exciting journey through the evolving field of BMT and cellular therapy.
For now, just create an account and enjoy this learning experience for free!
Claire Horgan and Nico Gagelmann,
on behalf of the EBMT Trainee Committee
- Provide trainees with a basic knowledge and understanding of bone marrow transplant and cellular therapies.
- Understand the processes involved in stem cell transplant.
- Familiarize trainees with important clinical aspects of stem cell transplant and cellular therapy, including pharmacology, patient monitoring, and recognition and basic management of complications.
Haematopoietic Stem Cell Niche
- Haematopoietic Stem Cell Niche Biology - Duygu Uçkan-Çetinkaya
- Understand the general concepts about stem cell biology, emerging concepts in the field of HSC biology, niche components, and regulation.
- Familiarise with the molecular mechanisms underlying HSC self-renewal and the differentiation within the HSC niche.
- Evaluate the factors in regulating HSC behaviour and niche interactions.
- Explore the heterogeneity of HSCs and how niche signals influence their fate decisions, including myeloid and lymphoid lineage commitment.
- Learn about the impact of aging on the HSC niche and its implications for haematopoietic disorders and regenerative medicine.
- Examine the dynamic nature of the HSC niche and how it responds to stress, injury, or disease states.
- Determine the potential therapeutic applications of manipulating the HSC niche, such as improving HCT outcomes.
- Graft-versus-host disease: Introduction - Zinaida Perić
- GvHD prevention: pharmacological strategies (part I & II) - Farhad Khimani
- Current approaches to prevent GvHD after allogeneic cell transplantation: graft manipulation - Antonio Pierini
- GvHD diagnosis and staging – acute & chronic - Olaf Penack
- GvHD Treatment: Acute GvHD - Maria Teresa Lupo-Stanghellini
- GvHD Treatment: Chronic GvHD - Maria Teresa Lupo-Stanghellini
- Understand the pathophysiology of graft-versus-host disease (GvHD).
- Learn about the different GvHD prevention platforms, including pharmacological and cell manipulation strategies.
- Learn about the side effects and interactions of the different GvHD prevention drugs.
- Diagnose and stage acute and chronic GvHD.
- Identify different treatment strategies for acute and chronic GvHD, including pharmacological and non-pharmacological approaches.
Acute Transplant Complications
- TMA - Sonata Jodele
- PRES - Rémy Duléry
- Engraftment Syndrome - Hemant S. Murthy
- Identifying and understanding acute complications after allogeneic haematopoietic cell transplantation (alloHCT).
Microbiome and Cellular Therapy
- Introduction to host microbiome and faecal microbiota transplantation - Florent Malard
- Microbiome and Haematopoietic Cell Transplantation - Jonathan U. Peled
- Modulation of Microbiome in HCT - Florent Malard
- Microbiota and CAR-T - Marcel R. M. van den Brink
- To familiarise with the general principles of the microbiome and related terms and its role in health and disease.
- To understand how the process of allogeneic HCT shifts gut microbiome, and how this alteration can predict clinical outcomes.
- To review the microbiome modulation approaches and discover the principles of faecal microbiota transplantation applied to HCT.
- To learn about the latest preclinical and clinical findings on microbiota and CAR-T cell therapy.
- Introduction to late complications - Bipin N. Savani
- Oncofertility for Women - Isabelle Demeestere
- Oncofertility for Men - Isabelle Demeestere
- Quality of - Hélène Schoemans
- Understand the need to focus on long-term follow-up after transplant.
- Learn about the different long-term post-transplant complications.
- Understand oncofertility complications that arise after transplant and that could affect both men’s and women’s health.
- Gain knowledge about the factors affecting the patients’ quality of life after stem cell transplantation.
Pharmacology Part 1: Conditioning
- Introduction to conditioning therapy - Daniele Avenoso
- CT in myeloid neoplasms AML/MDS/MPN - Vera Radici and Daniele Avenoso
- CT in ASCT in MM/amyloidosis - Samer Al Hadidi
- CT in lymphoid neoplasms: ALL - Brian D. Friend
- CT in lymphoid neoplasms: Autologous SCT - Abdul Hamid Bazarbachi
- CT in lymphoid neoplasms: Allo SCT for Hodgkin and NHL -Anna Sureda
- CT in Non Malignant conditions - Raffaella Greco
- Describe the rationale for using conditioning therapy before haematopoietic stem cell transplant.
- Discuss the commonly used conditioning regimens for different malignant and non-malignant indications.
- Summarize the frequently used agents and their common side effects and clinical considerations.
- VOD – diagnosis, risk factors and red flags, management, prognosis - Mohamad Mohty
- Acquire tools to identify patients at high risk of developing VOD/SOS and strategies to reduce this risk.
- Familiarise with key elements of diagnosis and risk stratification.
- Highlight the importance of early identification of VOD/SOS and early treatment initiation.
Finding the donor
- HLA typing and compatibility - Eric Spierings
- Donor types (part I) - Adriana Balduzzi
- Donor types (part II) - Adriana Balduzzi
- Donor types (part III) - Adriana Balduzzi
- Donor types (part IV) - Adriana Balduzzi
- Donor registries - Lydia Foeken
- Transplant coordination - Christina Holm
- To understand the main role of the human leukocyte antigen (HLA) system in immune responses and in the context of allogeneic haematopoietic cell transplantation.
- To gain insight into which criteria matter – and how – when selecting a donor for allogeneic transplantation.
- To understand the role and organisation of haematopoietic cell donor registries.
- To learn how an allogeneic transplantation is planned and coordinated.
Cellular therapy at home
- At-Home Stem Cell Transplantation - Francesc Fernández Avilés
- Outpatient/at-home management for CAR-T cell patients - Alexandra Martínez Roca
- Understand the logistic elements necessary to perform an at-home program for autologous and allogenic haematopoietic stem cell transplantation as well as CAR-T cell therapy.
- Identify how at-home programs can improve the quality of life of patients and caregivers and reduce medical costs.
- Recognise the prophylactic measures for preventing patient readmission.
- Assess the requirements to implement and manage at-home programs.
- Identify how to manage the adverse events in an outpatient/at-home setting.
Getting the Cells
- Bone marrow harvesting - Iñigo Romon
- Peripheral blood stem cell mobilization and apheresis - Daan Dierickx
- Procurement and management of cord blood - Sergio Querol
- Graft processing and manipulation - Sergio Querol
- Understand the procedure of bone marrow harvesting, including practical considerations, target cell yield, and potential risks and complications.
- Learn how haematopoietic progenitor cells (HPCs) are mobilised to and collected from peripheral blood, including the mechanism of action of G-CSF and the indications of different mobilisation regimes.
- Be able to identify and manage complications and side effects of HPC mobilisation and apheresis, including “poor mobilisers”.
- Understand how HPCs can be collected from cord blood and the setup of cord blood banks for this purpose.
- Gain knowledge about the main types of graft processing, including cryopreservation, plasma reduction, red blood cell depletion, and cell selection.