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MDS ATG versus Post-Cy in unrelated donors

Chronic Malignancies Working Party (CMWP)
Study type:
Study number:
Type of Stem Cell Treatment:
Allogeneic - Unrelated
Myelodysplastic (MDS) or MDS/MPN
Short title:
Primary objective:
The objective of the study is to evaluate the outcome of patients with MDS who underwent allogeneic HSCT and received GvHD prophylaxis with cyclophosphamide post-transplantation compared to those who received Antithymocyte Globulin (ATG).
The primary endpoint of the study is GvHD-free/relapse free survival (GRFS).
Key inclusion criteria:
o Diagnosis of MDS or MDS transformed to AML before first allogeneic HSCT.
o Adults (≥18 years) at time of transplantation.
o First allogeneic HSCT between 2012-2019.
o Stem cell source: bone marrow or peripheral blood from an unrelated donor.
o Post-cyclophosphamide (post-CY) as GvHD prophylaxis or Antithymocyte Globulin (ATG) as conditioning or GvHD prophylaxis treatment.
Principal investigator:
Yves Chalandon, Marie Robin
EBMT Study coordinator:
Laurien Baaij
Study coordinator email: