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JACIE Activity Report 2023

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JACIE celebrated its 25th Anniversary in 2023. Since 2003 JACIE has carried out 878 inspections in 32 countries. Of these, 48% have been initial inspections and 52% are re-accreditations. This has been only possible by the huge commitment and dedication by the Centres, Inspectors and all the Committee members supporting the process. 

 JACIE’s  goal – to harmonise and continually improve quality control standards in cellular therapy, initially across Europe, and now, beyond - remains as relevant as ever for all working in the field of Stem Cell transplantation and Cellular Therapies.

Activity update

JACIE received 97 applications in 2023 which is approximately 30 % increase in comparison to 2022.  17% of the applications were for the initial accreditation with 6 centres (6%) applying for the 4th re-accreditation. 

The number of inspections carried out by our inspectors increased to 77, which is the second highest number of inspections in JACIE history (2019: 78 inspections). This shows that JACIE has firmly returned to pre-pandemic activity and we are hugely grateful for all our inspectors, many of whom have carried out 2 or even 3 inspections in the course of the year. 

The number of centres accredited was 68 in comparison to 15 in 2022 and 27 in 2021. Huge thank you to the members of the Accreditation Committee who tirelessly reviewed the reports and for the Centres for the timely responses and for the inspectors for assessing the Evidence of Corrections submitted by the Centres. Achieving the JACIE Accreditation is nothing but teamwork.

Number of JACIE applications 2023Number of JACIE inspections 2023Number of JACIE Accreditation 2023

Institutions accredited in 2023

Facility Institution Country City
GhdC Charleroi - Autologous Stem Cells Transplantation Program Grand Hôpital de Charleroi GHdC asbl – Onco-Hematology Department Belgium Charleroi
Ziekenhuis Netwerk Antwerpen - ZNA Ziekenhuis Netwerk Antwerpen - ZNA Belgium Antwerp
Hematopoietic Stem Cell Transplant Program CHU UCL Namur CHU UCL Namur (site Godinne) Belgium Yvoir
Hematopoietisch stamceltransplantatieprogramma AZ Delta Belgium Roeselare
Stem Cell Transplantation Centre UZ Gent Belgium Gent
Stem Cell Transplantation Programme - Hematology UZ Brussel Belgium Brussels
Serviço de Transplante de Medula Óssea – Hospital São Rafael Hospital São Rafael Brazil Salvador - Bahia
Department of Internal Medicine, Hematology and Oncology University Hospital Brno Czech Republic Brno
Helsinki University Central Hospital, HUS Diagnostic Center, Stem Cell Laboratory Helsinki University Central Hospital, HUS Diagnostic Center, Stem Cell Laboratory Finland Helsinki
Centre Rouennais de Transplantation Pédiatrique de CSH Centre Hospitalo-Universitaire de Rouen France Rouen
Service d’hématologie et de thérapie cellulaire Hôpital Henri Mondor France Créteil
Service d’Aphérèse – SHOP (Service d’Hématologie et Oncologie Pédiatrique)  & Centre de Biothérapie d’Auvergne (CBA) – CHU Estaing CHU – site Estaing -   Service d’Aphérèse – SHOP & Centre de Biothérapie d’Auvergne France Clermont-Ferrand
Centre Léon Bérard Centre Léon Bérard France Lyon
Transplantation Program, Saint Louis Hospital AP-HP Hôpital St. Louis Ap-HP France Paris
Nice Cellular Therapy (NCT) Hopital Archet 1 – CHU de Nice France Nice
JACIE-CAEN CHU Caen Normandie France Caen
EFS PACA CORSE Laboratoire de Thérapie Cellulaire – Banque de cellules France Saint Laurent du Var
Centre Hospitalo-Universitaire de Poitiers /Establissement Français du Sang CHU de Poitiers France Poitiers
Pediatric Hematology Oncology - Toulouse University Hospital of Toulouse – Children’s Hospital France Toulouse
CHU de LILLE - Centre hospitalo-Universitaire de Lille, 
Unité de Thérapie Cellulaire and Centre Médico-Chirurgical Ambulatoire (CMCA)
Hôpital Claude Huriez France Lille
Hämatopoetische Stammzelltransplantation Universitätsklinikum Magdeburg AoR Germany Magdeburg
Klinik für Innere Medizin III Universitätsklinikum Ulm Germany Ulm
  III. Medizinische Klinik, Universitätsmedizin Mannheim and Institut für Transfusionsmedizin und Immunologie Medizinische Fakultät Mannheim der Universität Heidelberg, DRK-Blutspendedienst Baden-Württemberg – Hessen gGmbH Germany Mannheim
Dortmunder Centrum für Zelltransplantation - Standort St.-Johannes-Hospital  (DCZ-JoHo) Dortmunder Centrum für Zelltransplantation - Standort St.-Johannes-Hospital (DCZ-JoHo) Germany Dortmund
Division for SCT, Immunology and Intensive Medicine, Dept. for Children and Adolescents, University Hospital Frankfurt  - Pediatric Stem Cell Transplant Center Frankfurt/Main JWG - Johann Wolfgang Goethe University - University Hospital (Universitätsklinikum) Germany Frankfurt/Main
DRK-BSD BaWüHe Frankfurt DRK-BSD BaWüHe Frankfurt Germany Frankfurt/Main
Stem Cell Transplantation and Cellular Therapy Unit Evaggelismos Hospital Greece Athens
St. Vincent University Hospital St. Vincent University Hospital Ireland Dublin
BMT-Processing laboratory Sheba Medical Center, Tel-Hashomer Israel Ramat-Gan
Programma Congiunto Trapianto CSE e Terapia Cellulare Azienda Ospedaliero Universitaria Pisana (AOUP) Azienda Ospedaliero Universitaria Pisana (AOUP) Italy Pisa
Programma Trapianti Azienda Ospedaliera di Perugia Italy Perugia
PROGRAMMA TRAPIANTI Ospedale A.Perrino Italy Brindisi
Azienda Ospedaliero-Universitaria Consorzionale Policlinico di Bari Italy Bari
Programma Trapianti Ospedale Niguarda Grande Ospedale Metropolitano Ospedale Niguarda Italy Milan
Programma Trapianti Cellule Staminali  Emopoietiche Sezione Aferesi Terapeutica, Laboratorio di Manipolazione e Criopreservazione Cellulare  
Servizio Immunotrasfusionale e Genetica Umana,
Hematology Department
Ospedale San Bortolo Italy Vicenza
Centro Trapianto Midollo Osseo (CTMO) - Clinica Pediatrica dell’Università di Milano - Bicocca Fondazione MBBM Centro Trapianto Midollo Osseo (CTMO) Clinica Pediatrica dell’Università di Milano- Bicocca Fondazione MBBM Italy Monza
UOC Ematologia e Trapianto Emopoietico Ospedale AORN San Giuseppe Moscati Italy Avellino
Programma Trapianto di CSE in Pediatria IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di S. Orsola Italy Bologna
AOR Villa Sofia-Cervello AOR Villa Sofia-Cervello Italy Palermo
Hematopoietic Stem Cell Transplant American University of Beirut Medical Centre Lebanon Beirut
Centro de Hematologia y Medicina Interna Clinica Ruiz Mexico Puebla
Centre for Cell Therapy (Centrum voor Celtherapie) The Netherlands Cancer Institute - Antoni van Leeuwenhoek (NKI-AVL) Netherlands Amsterdam
Laboratory for Cell Therapy Sanquin Blood Supply Foundation Netherlands Amsterdam
Haemopoietic Cell Therapy & Transplant Programme,
Department of Haematology
Singapore General Hospital Singapore Singapore
Blood Transfusion Centre of Slovenia - Department of Therapeutic Services - Collection Centre Blood Transfusion Centre of Slovenia Slovenia Ljubljana
Programa de TPH, Department of Hematology Hospital Universitario Reina Sofía Spain Córdoba
Hospital Germans Trias i Pujol. Institut Català d'Oncologia Spain Badalona
Hematology Department Hospital de la Santa Creu i Sant Pau Spain Barcelona
Haemopoietic transplant and cellular therapy programme University Hospital Virgen del Rocio Spain Sevilla
Programa de Trasplante y Terapia celular Hospital Universitario de Salamanca Spain Salamanca
Unidad de Trasplante Hospital Universitario de Gran Canaria Dr. Negrín Spain Las Palmas de Gran Canaria
  Centro de Transfusión de la Comunidad Valenciana Spain Valencia
BST - Hospital Arnau de Vilanova Banc de Sang i Teixits Spain LLeida
Karolinska University Hospital Huddinge Cellular therapy and allogeneic stem cell transplantation, Clinical Immunology and Transfusion Medicine Sweden Stockholm
HSCT-programmet, Akademiska Sjukhuset University Hospital Sweden Uppsala
Barncancercentrum, The Queen Silvia Children's Hospital, Sahlgrenska University Barncancercentrum Sweden Göteborg
Klinik Hirslanden, Medizinisches Programm für Zelltherapie Klinik Hirslanden, Medizinisches Programm für Zelltherapie Switzerland Zürich
Southeast Scotland Haematopoietic Stem Cell Transplant Service Western General Hospital, Scottish National Blood Transfusion Service (SNBTS) United Kingdom Edinburgh
Stem Cell and Immunotherpay Department (SCI) Therapeutic Apheresis Service (TAS) NHS Blood and Transplant United Kingdom Oxford
Belfast City Hospital Belfast Health and Social Care Trust United Kingdom Belfast
Haematopoietic Stem Cell Transplant Programme Barts Health NHS Trust - St Bartholomew's Hospital United Kingdom London
St George’s University Hospital St. George's University Hospital - NHS Trust United Kingdom London
The London Clinic The London Clinic United Kingdom London
Paediatric Haematopoietic Stem Cell Transplantation & Bone Marrow Collection Programme - Royal Hospital for Children Royal Hospital for Children (NHS GREATER GLASGOW AND CLYDE) United Kingdom Glasgow
Nottingham University Hospital NHS trust Nottingham University Hospital City Campus United Kingdom Nottingham

JACIE Inspectors

The JACIE team continued the inspector training with the new format following the launch in November 2023. Three Inspector Training Courses took place in Barcelona, Paris and Istanbul with a total of 55 new inspectors trained. The Paris and Istanbul courses were run in collaboration with the National Transplant Societies and on behalf of JACIE we would like to extend our heartfelt thanks to these Societies for their support and collaborations.

JACIE launched the JACIE Inspector Handbook at the Annual Meeting in April 2023. The Handbook is provided to all inspectors to support them in their role with advice on the processes whether on how to book the travel or claim expenses to challenging Standards and how to assess them. The Handbook was developed in collaboration with the JACIE Inspector Committee who worked with the JACIE team to ensure that the information was both relevant and up to date.

Inspector Committee members also developed a proposal for improved Inspector Incentives, which was submitted for approval by the EBMT Board. This proposal was based on the survey in July 2023 that was sent to all active inspectors. Further updates will be available in 2024. However, as one of the first steps, JACIE was able to offer 72 grants for JACIE Inspectors to attend the EBMT 50th Annual Meeting in Glasgow 2024.

The Inspector Committee continued with the Webinar series for the Inspectors sharing best practice and updates on process and Standards.

Accreditation e-course for Centres

Together with the QMC, JACIE created the JACIE Accreditation e-course for Centres, a new, online, easy access, accreditation preparation course which aims to help all staff working in centres feel more confident in preparing for and undergoing the JACIE Inspection. The modules present information in a variety of formats, including presentations from experienced JACIE Quality Management Committee members as well as JACIE Accreditation Coordinators. The key objectives of the course is to help the Centre staff to understand the application process, to improve the understanding of some of the challenging Standards and how to comply, and lastly, to reduce any stress/anxiety around the accreditation process by supporting the Centres throughout the process. 

This new e-course is available to both members and non-members of the EBMT and is free to access at any time.

9th Edition Standards review process

FACT-JACIE Standards are reviewed every three years and the latest process for the 9th Edition of Standards commenced in June 2023 with a Steering Committee ‘kick-off’ meeting in June. The Steering Committee manages the overall process as well as makes all strategic decisions on the Standards. 

Five sub-committees (Clinical, Collection, Processing, Quality Management, and IEC) commenced their work in September 2023 with the work coordinated by the FACT office. The work will continue in 2024 with the Steering Committee meeting planned for February 2024, public consultation for summer 2023 and finally publication of the 9th edition in March 2025.