The aim of work package 5 is to develop standard criteria for the analysis and interpretation of the survival models that form the basis of assessment for the outcome of transplantation.
More specifically to:
- establish and maintain an information exchange infrastructure on the Methods used and biostatistical issues in the analysis of SCT data. This will provide access for clinicians and biostatisticians in Europe to each others methods and data and provides a source of practical methodological information needed to increase the quality of data analysis
- bring together biostatisticians to derive consensus on methodological issues that underpin the analysis of SCT data
- offer biostatisticians full access to analyses and data underlying published papers in peer reviewed journals
Description of work
| Task 1: |
To design and instigate an inventory of the existing bio-statistical literature on new but not-yet-widely applied statistical approaches in (SCT-related) survival analyses
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| Task 2: |
To focus on the application and interpretation of the methods collected in Task 1 and to extend where necessary such methods
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| Task 3: |
To make new approaches and methods readily available to the transplant research community in a practical way by integrating into the CLINT portal a methodological and biostatistical activity to provide current state-of-the-art knowledge to all biostatisticians involved in SCT research
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| Task 4: |
To encourage deposition of biostatistical analyses on the CLINT portal and to facilitate discussion of analyses and use of the site as an educational activity
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| Task 5: |
To design the appropriate analysis incorporating multiple (competing) endpoints including the actual occurrence of such an endpoint, time elapsed since treatment before and/or after events and solving problems in which the usual application and interpretation of the Cox model is not sufficient. This class of problems can be characterised by the fact that both the occurrence of multiple events as well as the actual time elapsed need to be modelled simultaneously in order to obtain clinically meaningful predictions of the probability and timing of such outcomes.
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| Task 6: |
To develop standardised guidelines on the analysis of SCT data
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For a progress report on the activities and deliverables related to the statistics work package visit work package 5