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Infectious Diseases

Introduction

The IDWP aims to promote and conduct educational activities and clinical investigations on all the topics concerning the diagnosis, the prophylaxis and the management of infectious complications following HSCT.

Members 



Chairperson
Jan Styczynski
jstyczynski@cm.umk.pl


Secretary
Malgorzata Mikulska
 
Study coordinator: Jennifer Hoek - idwp.ebmt@lumc.nl
 

New Study

A case-control study on risk factors, timing, and PCR use, for pneumocystis pneumonia (PcP) after allogeneic HSCT: A non-interventional prospective study of the EBMT Infectious Diseases Working Party.

This study aims to identify pre- and post-transplant factors associated with development of PcP after allogeneic HSCT.

Objectives

to report on:

  • the methods used for the diagnosis of PcP in the EBMT centers.
  • the timing of PcP after allogeneic HSCT.
  • the severity of the disease and the outcome at 30 days and 90 days after the diagnosis of PcP.
  • the specificities of the patients diagnosed only by PCR+ on BAL fluid, when compared to patients diagnosed by classical methods.
  • the immune status of PcP patients.
  • the prognostic factors to die from or with PcP, including co-infections.

Definition of PcP cases:

Any allogeneic HSCT recipient who, during the 1-year study period, underwent a BAL  from  the day of  transplant, and whose  BAL fluid was positive for PcP: either by qPCR alone, or  positive cytology or IF, irrespectively of clinical presentation, imaging, co-infection and PcP treatment. Only first episode of PcP will be included (incident cases).

Due to the lack of standardization, qPCR on sputum only will not be taken in account for the diagnosis of PcP.

Inclusion criteria of the PcP cases:

  • Allogeneic HSCT within the previous 24 months
  • New case (first onset) of PcP documented in a BAL fluid, whatever the positive diagnostic test (cytology or IF or PCR) and whatever the presentation and treatment
  • Any age

Research design:

This is a multicentre prospective case-control study performed in volunteer EBMT centers on a prospective 12 months period.

For each recruiting center, the technic of qPCR will be collected, and the participation in an external quality control will be proposed to the center.

A short specific Med C will collect the data of the PcP cases and controls.

When interested in participation please contact idwpebmt@lumc.nl

Related documents

Click HERE to view the publication list

Definitions of Infectious Diseases and Complications after Stem Cell Transplant   

How to start and develop a project with IDWP

Studies coordinated by the IDWP

Click HERE to view the Current Research list

 

  • Non-interventional prospective study on HHV-6 disease and HHV-6 chromosomal integration

  • Retrospective study on HHV-6 disease and HHV-6 chromosomal integration

How to get involved?

Please contact the Chairperson or the Secretary.



 

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