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van der Veken LT, Hoogeboom M, de Paus RA, Willemze R, Falkenburg JH, Heemskerk MH. HLA class II restricted T-cell receptor gene transfer generates CD4+ T cells with helper activity as well as cytotoxic capacity. Gene Ther. 2005 Dec;12(23):1686-95.

Kloosterboer FM, van Luxemburg-Heijs SA, van Soest RA, van Egmond HM, Willemze R, Falkenburg JH. Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia. Blood. 2005 Dec 1;106(12):3955-7. Epub 2005 Aug 11.

Hoogendoorn M, Olde Wolbers J, Smit WM, Schaafsma MR, Jedema I, Barge RM, Willemze R, Falkenburg JH. Primary allogeneic T-cell responses against mantle cell lymphoma antigen-presenting cells for adoptive immunotherapy after stem cell transplantation. Clin Cancer Res. 2005 Jul 15;11(14):5310-8.

Kloosterboer FM, van Luxemburg-Heijs SA, van Soest RA, van Egmond HM, Barbui AM, Strijbosch MP, Willemze R, Falkenburg JH. Minor histocompatibility antigen-specific T cells with multiple distinct specificities can be isolated by direct cloning of IFNgamma-secreting T cells from patients with relapsed leukemia responding to donor lymphocyte infusion. Leukemia. 2005 Jan;19(1):83-90.

van de Corput L, Chaux P, van der Meijden ED, De Plaen E, Frederik Falkenburg JH, van der Bruggen P. A novel approach to identify antigens recognized by CD4 T cells using complement-opsonized bacteria expressing a cDNA library. Leukemia. 2005 Feb;19(2):279-85.

Nijmeijer BA, van Schie ML, Verzaal P, Willemze R, Falkenburg JH. Responses to donor lymphocyte infusion for acute lymphoblastic leukemia may be determined by both qualitative and quantitative limitations of antileukemic T-cell responses as observed in an animal model for human leukemia. Exp Hematol. 2005 Oct;33(10):1172-81.

Velardi, A. NK cell adoptive immunotherapy. Blood. 105:3006

Ruggeri L, Capanni M, Mancusi A, Perruccio K, Burchielli E, Martelli MF, Velardi A. Natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation. Int J Hematol. 2005 Jan;81(1):13-7.

Ruggeri L, Mancusi A, Capanni M, Martelli MF, Velardi A. Exploitation of alloreactive NK cells in adoptive immunotherapy of cancer. Curr Opin Immunol. 2005 Apr;17(2):211-7.

Ruggeri L, Mancusi A, Perruccio K, Burchielli E, Martelli MF, Velardi A. Natural killer cell alloreactivity for leukemia therapy. J Immunother. 2005 May-Jun;28(3):175-82.

Ruggeri L, Capanni M, Mancusi A, Martelli MF, Velardi A. The impact of donor natural killer cell alloreactivity on allogeneic hematopoietic transplantation. Transpl Immunol. 2005 Aug;14(3-4):203-6.

Giebel S, Locatelli F, Wojnar J, Velardi A, Mina T, Giorgiani G, Krawczyk-Kulis M, Markiewicz M, Wylezol I, Holowiecki J. Homozygosity for human leucocyte antigen-C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen-C-matched unrelated donor haematopoietic stem cell transplantation. Br J Haematol. 2005 Nov;131(4):483-6.

Locatelli F, De Stefano P. T-cell depletion to prevent GVHD after unrelated-donor marrow transplantation. Lancet. 2005 Aug 27-Sep 2;366(9487):692-4.

Comoli P, Maccario R, Locatelli F, Valente U, Basso S, Garaventa A, Toma P, Botti G, Melioli G, Baldanti F, Nocera A, Perfumo F, Ginevri F. Treatment of EBV-related post-renal transplant lymphoproliferative disease with a tailored regimen including EBV-specific T cells. Am J Transplant. 2005 Jun;5(6):1415-22.

Giebel S, Locatelli F, Wojnar J, Velardi A, Mina T, Giorgiani G, Krawczyk-Kulis M, Markiewicz M, Wylezol I, Holowiecki J. Homozygosity for human leucocyte antigen-C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen-C-matched unrelated donor haematopoietic stem cell transplantation. Br J Haematol. 2005 Nov;131(4):483-6.

Ramirez M, Regidor C, Marugan I, Garcia-Conde J, Bueren JA, Fernandez MN. Engraftment kinetics of human CD34+ cells from cord blood and mobilized peripheral blood co-transplanted into NOD/SCID mice. Bone Marrow Transplant. 2005; 35(3):271-5

Rauser G, Einsele H, Sinzger C, Wernet D, Kuntz G, Assenmacher M, Campbell JD, Topp MS. Rapid regeneration of combined CMV-specific. Blood. 2004; 103(9):3565-72

Garcia et al. Other genetic polymorphisms: Killer cell immunoglobulin-like receptors (KIR). EBMT Handbook 2004 Revised Edition. 2004; EBMT Handbook 2004 Revised Edition

Paston et al. Immunotherapy with alloreactive cells? The Hematology Journal. 2004; 5:S91-S95

Paston et al. Progress made towards the development of a CMV peptide vaccine. Human Immunology. 2004; 65:544-549

Shaw et al. Scoring for HLA matching? A clinical test of HistCheck. BMT. 2004; 34:367-368

Shaw et al. Polymorphisms in the TNFA gene promoter region show evidence of strong linkage disequilibrium with HLA and are associated with delayed neutrophil engraftment in unrelted donor HSCT. Tissue Antigens. 2004; 63:401-411

Fernandez et al. Unrelated umbilical CBT in adults; early recovery of neutrophils by supportive co-transplantation of a low number of highly purified periheral blood CD34+ cells from an HLA-hapoloidental donor. Exp Hematol. 2003; 31:535-544

Spierings et al. The minor histocompatibility antigen HL-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein. Blood. 2003; 102:621-629

Spierings et al. Identification of HLA class II-restricted H-Y-specific T-helper epitope evoking CD4+ T-helper cells in H-Y-mismatched transplantation. Lancet. 2003; 362:610-615

Dickinson et al. In situ dissection of the graft-versus-host. Nature Medicine. 2002; 8:410-414

Velardi et al. NK cells: a lesson from mismatched hematopoietic transplantation. Trends in Immunol. 2002; 23:438-444

Ruggeri et al. Effectiveness of donor natural killer cell. Science 2002; 295:2097-2100

Gluckman E;Rocha V;Chevret S;. Results of unrelated umbilical cord blood hematopoietic stem cell transplant. Transfus Clin Biol. 2001; 8:146-154

Gluckman E;Rocha V;Chevret S; Results of unrelated umbilical cord blood hematopoietic stem cell transplantation. Rev Clin Exp Hematol. 2001; 5:87-99

Clark et al. Direct evidence that leukaemic cells present HLA-associated. Blood. 2001; 98:2887-2893

Creaser et al. Characterisation of HLA-A3 restricted peptide. Adv Mass Spectrom. 2001; 18:637-638

Aubert et al. Cytomegalovirus-specific cellular immune responses and viremia in recipients of allogeneic stem cell transplants. J Infect Dis 2001; 184:955-963

Gluckman E; Current status of umbilical cord blood hematopoietic stem cell transplantation. Exp Hematol. 2000; 28:1197-1205

EBMT News Updates (click on the pdf symbol)

July 2004 (Allostem)