Prospective Clinical Trials

• MMVAR
  A randomized controlled study of Velcade (Bortezomib) plus Thalidomide plus Dexamethasone compared to Thalidomide plus Dexamethasone for the treatment of myeloma patients progressing or relapsing after autologous transplantation.
  
  • SAE/Pregnancy Report webpage
    
  • SAE/Pregnancy webpage guidelines
  • Updates of this trial can be seen by clicking here

• RICMAC
  Dose-reduced versus standard conditioning followed by allogeneic stem cell transplantation in patients with MDS or sAML.
  A randomised phase III study.

• AUTO-CLL
  The value of autografting in younger patients with high risk CLL

• AlloMDS 2x2
  Double randomisation in patients with MDS:
  immediate AlloTransplantation versus AlloTransplantation after remission induction and Peripheral Blood versus Bone Marrow stem cells

• AlloRIC-MMM
  Allogeneic stem cell transplantation after dose-reduced intensity conditioning regimen for patients with myelofibrosis with myeloid metaplasia (MMM):
  A phase II-study
  

• CML Relapse
  Phase III randomized study of donor lymphocyte infusions vs Imatinib followed by donor lymphocyte infusions for relapse after allogeneic blood or marrow transplant for Chronic Myeloid Leukemia

• AlloRIC-CLL
  EBMT protocol platform on reduced-intensity conditioning allografting for chronic lymphocytic leukemia (CLL). (P Dreger)
  Click on the link to download:
  • the EBMT/GCLLSG CLL3X protocol (amended feb. 2004)
  • the CRF's

• NMAM2000
  A Phase II study comparing non-myeloablative allogeneic hematopoietic stem cell transplantation following autologous transplantation to autologous transplantation alone in multiple myeloma (Gösta Gahrton)

• OKT3
  A randomised study of OKT3 plus cortico steroids versus high dose steroids for the treatment of severe acute GVHD (H Einsele)