Transplant Activity Survey

Background

In 1990, the EBMT introduced an annual survey to prospectively collect numbers of patients treated with a hematopoetic stem cell transplant according to indication, donor type and stem cell source. Its importance was immediately realised and since then, the survey has become an instrumental tool for assessing the real picture of HSCT in Europe, recognising trends, illustrating the current status and providing essential data for counselling and planning. This survey is relevant to health care agencies, industries as well as patients. In addition, it serves as a quality control instrument for comparison with national agencies or for the EBMT auditing process.

All transplant teams are invited to join the survey: for EBMT members it is a mandatory process, for non-members it is voluntary.

Participate in the Activity Survey 2008

Participate in the 2008 Activity Survey. Note that the Med A data reported to the EBMT Med AB database -Promise- is not automatically included in the Activity Survey. Even if you report your transplant data to the EBMT, by paper Med A form, electronically with the ProMISe system or via a National Registry, please report to this survey too.

• EBMT Calender Year Survey 2008 download in either excel pdf
• Guidelines for Activity Survey 2008
• Letter requesting CIC participation in Activity Survey 2008

Instructions:

1. Click on the link 'EBMT Calender Year Survey 2008'
2. Save the file to your Desktop or another easy to remember location.
3. Name the file "CIC (your number)". If you do not have a CIC number, call the file after your institution.
4. Complete the data fields.
5. Email the form to the survey coordinator at baldomeroh@uhbs.ch.
The 2008 calendar year survey may be accessed by clicking on the link above. We recommend that you read the guidelines carefully before filling out the survey.

Guidelines for reporting data to the EBMT Activity Survey 2008.

Table 1: Report the total number of patients receiving their 1st transplant in your centre in 2008. Report the first allogeneic transplant and/or first autologous transplant per patient according to disease indication, donor type and stem cell source as outlined in Table 1. You may include the same patient twice as long as the first occurrence of each type of transplant took place in 2008.

The following EBMT/JACIE/FACT definitions for ‘first transplants’ apply:

• first transplant (new patient, never transplanted before)
• first allograft (after a previous autograft) or first autograft (after a previous allograft)
• first allograft or first autograft in your centre after a previous transplant in a different centre.

The column ‘total allo after auto’ refers to patients with their disease treatment in a planned ‘allo after auto’ transplant programme. Enter these patients in both the respective allogeneic or autologous transplant section in the main table and in the column ‘total allo after auto’ on the right side.

The following definitions for donor type and stem cell source apply:

• Non-id = any family member (matched or mismatched) other than HLA-identical sibling or twin.

For combinations of stem cell products / donor types:

• Bone marrow and peripheral blood = peripheral blood stem cell transplant - enter as PBSC
• Bone marrow and cord blood = cord blood transplant - enter as Cord
• Peripheral blood and cord blood = cord blood transplant - enter as Cord
• Bone marrow and peripheral blood + cord blood = cord blood transplant - enter as Cord
• Autologous stem cells given together with an allogeneic transplant within 7 days = allogeneic transplant
• Multiple infusions, e.g. double cord, multiple cord, multiple PBSC within one week are reported as one transplant only.

Table 2: Report the total number of retransplants and additional (non-first) transplants performed with allogeneic BM, PBSC or Cord blood in 2008.

Table 3: Report the total number of retransplants and additional (non first) transplants performed with autologous BM, PBSC or Cord blood in 2008

The following definitions for table 2 and 3 apply only if the rules for 1st transplants do not apply:

• A Retransplant is an unplanned transplant performed due to relapse, rejection of the first transplant or for any other secondary malignancy.
• An Additional transplant (non-first transplant) is when a double, triple or more ‘multiple graft programme’ is planned from the beginning of the treatment protocol.
• Re-infusion of allogeneic stem cells for graft failure is considered to be a retransplant. Enter in Table 2 as a retransplant.
• Re-infusion of autologous stem cells for non-engraftment is considered to be a boost and is not a transplant.

Table 4: collects generic information (i.e. total numbers only) on additional cellular therapies or technologies.

• Cord Blood: enter the total number of all cord blood transplants performed in 2008.
• RIC (Reduced Intensity Conditioning transplants): enter the total number of all RIC transplants performed in 2008 (this includes first HSCT from Table 1 and/or re- or additional HSCT from Table 2).
• DLI (Donor Lymphocyte Infusions): enter the total number of patients receiving DLI in 2008. The year of transplant does not effect the DLI reporting.
• MSC (Mesenchymal stromal cells): enter the total numbers on MSC stromal cell transplants performed in 2008.

• Cell transplants for non-hematopoietic use: enter the number of patients receiving cell transplants for NON-hematopoietic use in 2008.

Table 5: To calculate the total number of transplants in 2008: add together the total number of allogeneic transplants from Table 1 + Table 2 = Total allo HSCT and the total number of autologous transplants from Table 1 + Table 3 = Total auto HSCT to provide the total number of ALL TRANPLANTS performed in 2008.

Please use the document 'Reduced Intensity Conditioning definitions' drafted in 2005 by the EBMT Definitions Committee in London to aid your reporting of RIC (mini allo) transplants.

Please also use the ´disease definitions document´ for defining any indications that you are unsure about.

Should you have any questions regarding the Activity survey please contact:

Helen Baldomero: Tel: +41 61 2653203; Fax: +41 61 265 2735; E mail: baldomeroh@uhbs.ch

Summary Slides

Data from the most recent survey year are available only to EBMT members using their username and password. Please contact the EBMT secretariat with any password queries or difficulties.

Transplant Activity Survey 2007

Overview of HSCT in Europe 2007

Transplant Activity Survey 2006

Overview of HSCT in Europe 2006


Transplant Activity Survey 2005

Overview of HSCT in Europe 2005


Transplant Activity Survey 2004

Overview of HSCT in Europe 2004

Please note that this data has not yet been published and should be treated as confidential. It is for internal use only and may not be used for publication without obtaining prior consent from Prof. Alois Gratwohl, Head of the survey.

Please contact Helen Baldomero should you have any questions regarding the Activity survey. Tel: +41 61 2653203 baldomeroh@uhbs.ch.

Previous years

• Activity survey archive (open access)

Publications

The EBMT activity survey 2007 with focus on allogeneic HSCT for AML
and novel cellular therapies

A Gratwohl, H Baldomero, A Schwendener, V Rocha, J Apperley, K Frauendorfer and
DNiederwieser, for the Joint Accreditation Committee of the International Society for Cellular Therapy ISCT and the European Group for Blood and Marrow Transplantation EBMT (JACIE)

Why are there regional differences in Stem Cell Transplantation Activity? An EBMT Analysis
A Gratwohl, H Baldomero, K Frauendorfer and D Niederwieser, for the Joint Accreditation
Committee of the International Society for Cellular Therapy ISCT and the European Group
for Blood and Marrow Transplantation EBMT (JACIE)

Activity Survey 2006: Focus on the use of cord blood products
A.Gratwohl, H.Baldomero,.K.Frauendorfer, V.Rocha, J.Apperley and D.Niederwieser,for the Joint Accreditation Committee of the International Society for Cellular Therapy ISCT and the European Group for Blood and Marrow Transplantation EBMT(JACIE)

Predictability of Hematopoietic Stem Cell Transplantation Rates
Alois Gratwohl, Helen Baldomero, Alvin Schwendener, Michael Gratwohl, Jane Apperley,Dietger Niederwieser, Karl Frauendorfer for the Joint Accreditation Committee of theInternational Society for Cellular Therapy (ISCT), the European Group for Blood and MarrowTransplantation (EBMT) (JACIE) and for the European Leukemia Net

Haematopoietic stem-cell tranplants for Chronic Myeloid Leukemia in Europe. Impact of
cost consideration. A.Gratwohl, H. Baldomero, A. Schwendener, M.Gratwohl, A. Urbano.Ipizua,and K. Frauendorfer for the Joint Accreditation Committee of the International Society for Cellular Therapy ISCT and the European Group for Blood and Marrow Transplantation EBMT (JACIE). Division of Hematology, Department of Medicine, University Hospital Basel, Basel, Switzerland. Institute for Operations Research and Computational Finance, University of St. Gallen, St. Gallen, Switzerland and JACIE Office, Hospital Clinic, Barcelona, Spain.

Results of the EBMT Acitivity Survey 2005 on haematopoietic stem cell transplantation: a focus on increasing use of unrelated donors. A Gratwohl, H.Baldomero, K.Frauendorfer, A.Urbano-Ispizua, and D.Niederwieser, for the Joint Accreditation Committee of the International Society for Cellular Therapy ISCT and the European Group for Blood and Marrow Transplantation EBMT (JACIE).

Change in stem cell source for hematopoietic stem cell transplantation (HSCT) in Europe: a report of the EBMT activity survey 2003. A Gratwohl, H Baldomero, O Schmid, B Horisberger, M Bargetzi and A Urbano-Ispizua for the Joint Accreditation Committee of the International Society for Cellular Therapy ISCT and the European Group for Blood and Marrow Transplantation EBMT (JACIE). Bone Marrow Transplantation 08/08/05 doi:10.1038/sj.bmt.1705104. 437 kb

Evolution of Hematopoietic Stem Cell Transplantation in Eastern andWestern Europe from 1990 to 2003. A Report from the EBMT Activity Survey. Alois Gratwohl, Helen Baldomero, Boris Labar, Jane Apperley, Alvaro Urbano-Ispizua for the Accreditation Committee of the European Group for Blood and Marrow Transplantation (EBMT). CMJ (2004) 45(6):689-694 150 kb

Haematopoietic stem cell transplantation (HSCT) in Europe 2002. Changes in indication and impact of team density. A report of the EBMT activity survey. A Gratwohl, O Schmid, H Baldomero, B Horisberger and A Urbano-Ispizua, for the Accreditation Committee of the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplantation (2004) 34, 855–875 418 kb

EBMT EHA Transplantation Overview of transplant activity in Europe. Alois Gratwohl for the EBMT JACIE Accreditation Office. The Hematology Journal (2004), Volume 5, Supplement 3, Pages S29-S33

A. Gratwohl, H. Baldomero, T. Demirer, G. Rosti, G. Dini, R. Ladenstein & A. Urbano-Ispizua. On behalf of the Accreditation Committee of the European Group for Blood and Marrow Transplantation (EBMT) in cooperation with the Working Party on Solid Tumours (STWP) and the Working Party on Pediatric Diseases (PDWP) Hematopoetic stem cell transplantation for solid tumors in Europe. Annals of Oncology 15: 653-660, 2004 1.13mb | Appendix 65kb

A Gratwohl, H Baldomero, J Passweg, F Frassoni, D Niederwieser, N Schmitz and A Urbano-Ispizua for the Accreditation Committee of the European Group for Blood and Marrow Transplantation (EBMT) in cooperation with the Working Parties Acute (ALWP) and Chronic Leukemias (CLWP) and the Lymphoma Working Party. Hematopoietic stem cell transplantation for hematological malignancies in Europe. Leukemia (2003) 17, 941-959

Gratwohl A. The role of the EBMT activity survey in the management of hematopoietic stem cell transplantation. European Group for Blood Marrow Transplantation. Int J Hematol. 2002 Aug;76 Suppl 1:386-92.

A Gratwohl, H Baldomero, J Passweg and A Urbano-Ispizua for the Accreditation Committee of the European Group for Blood and Marrow Transplantation (EBMT). Special report: Increasing use of reduced intensity conditioning transplants: report of the 2001 EBMT activity survey. Bone Marrow Transplantation (2002)30, 813-831

Gratwohl A, Baldomero H, Horisberger B, Schmid C, Passweg J and Urbano-Ispizua A. Current Trends in Hematopoetic Stem Cell Transplantation in Europe. Blood 100: 2374-2386, 2002-10-24, prepublished online May 31, 2002.

Gratwohl A, Passweg J, Baldomero H, Horisberger B, Urbano-Ispizua A. Economics, health care systems and utilization of haematopoietic stem cell transplants in Europe. Br J Haematol. 2002 May;117(2):451-68. PMID: 11972533

Gratwohl A, Baldomero H, Urbano-Ispizua A. Transplantation in chronic myeloid leukaemia. Lancet. 2002 Feb 23;359(9307):712-3. PMID: 11879900

Gratwohl A, Baldomero H. Stem cell transplant numbers decline; research continues. J Natl Cancer Inst. 2001 Jun 20;93(12):949. PMID: 11416117

Gratwohl A, Baldomero H, Rosti G. High-dose chemotherapy for breast cancer. Bone Marrow Transplant. 2000 Sep;26(6):599. PMID: 11041563

Gratwohl A, Passweg J, Baldomero H, Urbano-Ispizua A for the European Group for Blood and Marrow Transplantation (EBMT). Hematopoietic stem cell transplantation activity in Europe 1999. Bone Marrow Transplant. 2001;27:899-916.

Gratwohl A, Passweg J, Baldomero H, Hermans J. Blood and marrow transplantation activity in Europe 1997. European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant. 1999;Aug24(3):231-45. PMID: 10456992

Gratwohl A, Baldomero H and Hermans J. Quantitative Assessment of Consensus on Indications for Blood or Marrow Transplantation in Europe 1995. Cancer Research Therapy and Control, 1999, Vol. 10, pp. 123-144

Gratwohl A, Passweg J, Baldomero H, Hermans J and Urbano-Ispizua A for the European Group for Blood and Marrow Transplantation. Hematopoietic stem cell transplantation in Europe 1998. The Hematology Journal. 2000;1:333-350.

Gratwohl A, Passweg J, Baldomero H, Hermans J. Blood and marrow transplantation activity in Europe 1996. European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant. 1998;Aug22(3):227-40. PMID: 9720735.

Gratwohl A, Hermans J, Baldomero H. Blood and marrow transplantation activity in Europe 1995. European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant. 1997;Mar;19(5):407-19. PMID: 9052905

Gratwohl A, Hermans J, Baldomero H. Hematopoietic precursor cell transplants in Europe: activity in 1994. Report from the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant. 1996; Feb;17(2):137-48. PMID: 8640158

Gratwohl A, Hermans J, Baldomero H, Tichelli A, Goldman JM and Gahrton G for the European Group for Blood and Marrow Transplantation (EBMT). Indications for haematopoietic cell transplants in Europe. British Journal Haematology, 1996;92:35-43.

Gratwohl A, Hermans J. Indications and donor source of hematopoietic stem cell transplants in Europe 1993: report from the European Group for Blood and Marrow Transplantation (EBMT). Clin Transplant. 1995;Oct;9(5):355-63. PMID: 8541627

Gratwohl A. Incidence of bone marrow transplantation in Europe. Report from the European Group for Blood and Marrow Transplantation. Arch Immunol Ther Exp (Warsz). 1995;43(2):77-81. PMID: 8744719

Gratwohl A, Hermans J. Bone marrow transplantation activity in Europe 1992: report from the European Group for Bone Marrow Transplantation (EBMT). Bone Marrow Transplant. 1994;Jan;13(1):5-10. PMID: 8019452

Gratwohl A, Hermans J. EBMT survey on bone marrow transplant activity in Europe: regional differences. Bone Marrow Transplant 1994;Jun;13(6):683-8. PMID: 7920292

A. Gratwohl, J. Hermans, J.M. Goldman and G. Gahrton for the European Group for Bone Marrow Transplantation (EBMT). Bone marrow transplantation in Europe: major geographical differences. Journal of Internal Medicine 1993;233:333-341.

Gratwohl A. Bone marrow transplantation activity in Europe 1990. European Group for Bone Marrow Transplantation (EBMT) Bone Marrow Transplant.1991;Sep;8(3):197-201. PMID: 1958899

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